Prostatic Cancer
نویسندگان
چکیده
IN 1941 research in prostatic cancer received great impetus from the discovery by Huggins and his associates 1 that remarkable regression occurred clinically in the primary neoplasm and its metastases after castration or administration of estrogen. These findings were subsequently verified by others.2 Unfortunately, the gratifying improvement manifested by most patients treated in this manner has since been found to be only temporary, and no actual cures have ever been recorded. Furthermore, postmortem studies on patients in whom no palpable or roentgenologic evidence of local or distant recurrence was evident just before death have shown extensive involvement of the prostate, bones and soft tissues. In all cases in which radical perineal prostatectomy has been done for advanced cancer after preoperative administration of
منابع مشابه
Endothelin-1 expression in prostate needle biopsy specimens correlated with aggressiveness of prostatic cancer
Background & Objective: As the prostate adenocarcinoma is one of the most common malignant tumors in males, looking for a marker to effectively predict aggressiveness and metastatic potential in an apparently localized cancer in initial needle biopsy specimens can help the clinicians to make more appropriate decision for treatment, planning, and choosing appropriate ta...
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Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than 100 types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-16 and HPV-18 have shown further association with cancer. Regarding the pr...
متن کاملبررسی شیوع نئوپلازی داخل اپیتلیالی با درجه بالا در نمونههای پروستات و همراهی آن با کانسر پروستات در مراجعهکنندگان به بیمارستان شهید هاشمینژاد از سال 1378 لغایت 1379
In this study incidence of H.G. Prostatic intraepithelial neoplasia and concurrent Prostatic cancer is evaluated. we reviewed the slides of 137 cases of prostatic specimens (1999-2000) in hashemi nejad Hospital, that consists of needle biopsy, total prostatectomy and transurethral resection for H.G. prostatic intraepithelial neoplasia and concurrent cancer. Based on the pathologic repo...
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Introduction: Prostate cancer is the second most common cancer and the leading cause of cancer-related deaths worldwide. In the present study, the expression level of glycine N-methyl transferase gene (GNMT) was investigated in prostate cancer tissue. The GNMT enzyme is encoded by the GNMT gene. Increased GNMT gene expression increases the conversion of glycine to sarcosine and results in the e...
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Background and Aims: Prostate cancer is the second most common cancer in men worldwide in men. Matrix metalloproteinase 2 (MMP2) has a role in the invasion and destruction of the basement membrane and the extra-cellular matrix and facilitating the process of tumor cell invasion. The present study was conducted to compare the expression of MMP2 gene in prostate cancer (PCa) and benign prostatic ...
متن کاملCorrelation between staining intensity of prostatic adenocarcinoma with P53 and Gleason's grading
Introduction: Prostatic adenocarcinoma is the most common malignancy of internal system and after lung cancer is the second cause of death in male. Genetic base of many neoplasms is related to suppressor tumor gene such as P53. Therefore, we aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with P53 staining method and its relationship with Gleason grade. ...
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